If you have the skills and equipment to drill AND bend, it is best to drill the whole thing, to the extent you can plan, then cut and bend. As you probably know, it is easier to drill the metal when it is flat. Things to watch out for:
-sockets not too close to the edge.
-transformers not too close to the edge
-adequate room between components...particularly if you will be using coke bottle shaped tubes or chicken head knobs
-on front and back panel, remember to make sure placement (of switches, for example) allows adequate clearance for soldering wires, etc.
-bend a pair of lips for mounting to a cabinet -- simplest mount is about .75" on each (short) side bent outwards, but probably not the simplest bend -- simplest bend is probably two inward lips on the long sides.
-no oversize holes
Look around for drilling plans that already exist. There will be good hints for things.
Give it a try, particularly if you think you can do it. You can always move to plan B if that doesn't pan out!